Figure 1: The spliceosome is required for cells to tolerate oncogenic MYC hyperactivation. BUD31 has been linked to the spliceosome in yeast 10, but its function in mammalian systems has not been ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

A number of compounds, derived from bacterial fermentation products, have been found to target subunits of the spliceosome and display anticancer properties. In this Review, Valcárcel and ...

Cancer's 'Achilles' Heel' One of the most significant findings in the study is that the spliceosome is highly interconnected, where disrupting one component can have widespread ripple effects ...

For example, the study manipulated the spliceosome component SF3B1, which is known to be mutated in many cancers including melanoma, leukemia and breast cancer.

For example, the study manipulated the spliceosome component SF3B1, which is known to be mutated in many cancers including melanoma, leukaemia and breast cancer. It is also a target for anti-cancer ...

Previously unknown driver of prostate cancer identified"We took a closer look at a certain molecular machine called the spliceosome", explains Anke Augspach, lead author of the study and ...

The spliceosome complex was found to be interconnected, with disruptions in one portion having significant effects on other parts of the complex. "Their reliance on a highly interconnected splicing ...

In addition to proteins, the spliceosome is also composed of small nuclear RNAs (snRNAs) that are responsible for splice site recognition and were long thought to be basal elements of the spliceosome.

In their investigations, the team found various indications for the central role of the minor spliceosome in cancer. "We were able to show that a specific component of the minor spliceosome is ...

During splicing, this transcript undergoes modification: a cellular editing complex, the spliceosome, ... "Blocking USP39 in these cancer cells could selectively kill them," Đikić explains ...