are one of the main causes of inheritable genetic disorders and are associated with neurodevelopmental disorders and diseases such as cancer. It was known that the spliceosome has quality control ...

such as the transcription factor c-MYC and spliceosome mutations, confer vulnerabilities across multiple levels of RNA processing. • How mammalian cells respond to broad aberrations in RNA processing ...

The fit between a splice site and the spliceosome components that bind it influences splicing activity. Strong splice sites closely match consensus sequences and are efficiently recognized by the ...

Proper splicing requires efficient spliceosome assembly ... A mechanistic study reveals that RBPMS suppresses bladder cancer cell migration by regulating alternative splicing of ANKRD10, which ...

Get Instant Summarized Text (Gist) A new regulatory mechanism in RNA splicing has been identified, involving LUC7 proteins that influence spliceosome targeting of specific 5' splice sites. This ...