Intron removal requires assembly of the spliceosome on precursor mRNA (pre-mRNA) and extensive remodelling to form the spliceosome’s catalytic centre. Here we report the cryo-electron microscopy ...

Catalytic spliceosome captured. In the ILS″ structure, DHX15 unambiguously binds the U6 snRNA (in a state in which DHX15 is not bound to the energy-providing molecule ATP), ...

They also found remarkable similarities in structure and function between spliceosome RNAs and group II introns, an evolutionarily-ancient class of self-splicing, catalytic RNA found in all major ...