Its long-separated twin—the minor spliceosome, is much more scarce and remains enigmatic, even though its function is equally important. In this study, the researchers reveal the structure of ...

"The largely stable structure of the spliceosome center enabled us to obtain high-resolution information. This means that a spliceosome discarded during cellular quality control can be represented ...

What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms. Next, the snRNPs U2 and U4/U6 appear to ...

Get Instant Summarized Text (Gist) A new regulatory mechanism in RNA splicing has been identified, involving LUC7 proteins that influence spliceosome targeting of specific 5' splice sites. This ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

Proper splicing requires efficient spliceosome assembly ... The cis-regulatory elements encoded in the sequence and structure of mRNAs determine their translational output. Here the authors ...