A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA.

During splicing, this transcript undergoes modification: a cellular editing complex, the spliceosome, removes certain segments. The outcome varies depending on which parts are cut out, resulting ...

Structural biologists provide a first-time look at the atomic level into the quality control mechanism of this complex molecular machine A complex molecular machine, the spliceosome, ensures that ...