Researchers at the Center for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome ...

For example, the study manipulated the spliceosome component SF3B1, which is known to be mutated in many cancers including melanoma, leukaemia and breast cancer.

For example, the study manipulated the spliceosome component SF3B1, which is known to be mutated in many cancers including melanoma, leukemia and breast cancer.

For example, the study manipulated the spliceosome component SF3B1, which is known to be mutated in many cancers including melanoma, leukaemia and breast cancer. It is also a target for anti-cancer ...

RNA-sequencing has become a cornerstone in the study of gene expression, offering insights beyond mere mRNA transcript abundances. One area of increasing interest is alternative splicing, a ...

About half of MDS patients carry genetic alterations, also known as somatic mutations, in the spliceosome genes, with SF3B1 being the most common one. However, no successful therapy exists to ...

SF3B1 is the most mutated spliceosome gene in cancer, in particular in leukaemia, uveal melanoma, pancreatic, and prostate cancer. The researchers discovered that two molecular motors reshape SF3B1, ...

Structures of aberrant spliceosome intermediates on their way to disassembly. Nature Structural & Molecular Biology , 2025; DOI: 10.1038/s41594-024-01480-7 Cite This Page : ...

The spliceosome is the molecular machine in our cells that puts the blueprints for proteins into a readable form. Researchers at the Max Planck Institute (MPI) for Multidisciplinary Sciences in ...

For example, the study manipulated the spliceosome component SF3B1, which is known to be mutated in many cancers including melanoma, leukaemia and breast cancer.