Researchers unveil detailed structural insights into the minor spliceosome, shedding light on its role in gene expression and potential disease implications.

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

C-complex spliceosomes were assembled and purified as described 9 with the following exception: before affinity purification, we added 1 nmol Beta-PP7 to the spliceosome-containing fractions and ...

After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

The Spliceosome Comes Assembled Graphic: Courtesy of Scott Stevens ASSEMBLY INSTRUCTIONS: In the penta-snRNP model, all five spliceosomal snRNPs interact with the substrate pre-mRNA as a single, ...

The spliceosome does the genetic cutting and pasting. It is a complicated complex, made up of four major parts and more than 100 accessory proteins that come together and break apart throughout the ...

Detailed map of the spliceosome is being made publicly available to help researchers pinpoint exactly where splicing errors are occurring in a patient's cells.

The compositional complexity of the spliceosome creates a serious obstacle for its experimental analysis. Purification of a compositionally defined splicing complex C capable of completing the ...

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The spliceosome does the genetic cutting and pasting. It is a complicated complex, made up of four major parts and more than 100 accessory proteins that come together and break apart throughout ...