Spliceosomes are large and dynamic RNA-protein complexes. The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps ...

"The spliceosome is composed of multiple components that secure production of functional proteins controlling cellular life," explains Đikić. "If this complex is disrupted, it can lead to the ...

Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...

The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps") -- and about 150 proteins, involved in different stages of ...

Feb. 2, 2024 — A study has identified a protein complex that is activated by defects in the spliceosome, the molecular scissors that process genetic information. Future research could lead to ...

Precursor messenger RNA is edited into its final form by an RNA–protein assembly called the spliceosome. Structural evidence provides insights into how the spliceosome is disassembled when its ...

The spliceosome is the collection of 150 different proteins and five small RNA molecules that orchestrate the RNA editing process, but until now, the specific roles of its numerous components were ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

To sustain life, processes in biological cells have to be strictly controlled both in time and in space. Research workers at the Max Planck Institute for Biophysical Chemistry in Göttingen and ...

This process is controlled by a large protein-RNA complex called the spliceosome. MIT biologists have now discovered a new layer of regulation that helps to determine which sites on the messenger ...

Atomic-resolution structures have recently been obtained for the intact spliceosome at different stages of the splicing cycle. These structural data have proved that the spliceosome is a protein ...

video: Video of spliceosomes -- the complex of specialized RNA and protein subunits that acts as molecular scissors and tape during gene transcription -- at work. view more Credit: University of ...