A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

The U2 snRNP particle is an essential component of the eukaryotic pre-mRNA splicing apparatus, the spliceosome. Natural and semisynthetic inhibitors that bind the SF3b subunit of the U2 snRNP ...

Researchers have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine in human biology. The vast majority of human genes -- more than nine in ten ...

After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

The traditional view posits that spliceosome formation is a stepwise affair, with one snRNP binding to the pre-mRNA first, followed by the others in a temporal order. This model is widely held as ...

Researchers have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine inside every cell.

New research published in eLife and led by Professor Michael Sattler, Director of the Institute of Structural Biology (STB) at Helmholtz Zentrum München has revealed more about Fas splicing and how an ...

The Galej Group at EMBL Grenoble has recently published new structural insights into minor spliceosome function in the journal Molecular Cell.

Researchers at the Centre for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine in human biology ...