The fit between a splice site and the spliceosome components that bind it influences splicing ... At the posttranscriptional level, nonsense mediated decay (NMD) is a process closely linked to ...

Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...

They succeeded once they were able to isolate the splicing complexes of the fungus that were in the midst of quality control ...

The process of RNA splicing by the spliceosome helps to generate molecular diversity beyond the genome sequence. In the May 3 Science, Tyson Clark and colleagues at the University of California, Santa ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

Proper splicing requires efficient spliceosome assembly ... a key component of nonsense-mediated mRNA decay (NMD), during cellular senescence and its impact on NMD efficiency, leading to the ...

While GPATCH1 detects the defective pre-mRNA, DHX35 removes it from the spliceosome, which is subsequently disassembled and made available for a new round of splicing. Two molecular control ...

Splicing is catalyzed by a large molecular machine. This spliceosome is made up of variety of protein and RNA components, and for each splicing process, it is reassembled at the sites where an ...