What is the spliceosome? At the core of the splicing process is the spliceosome, a highly intricate molecular complex responsible for removing introns from pre-mRNA. 1 Composed of small nuclear RNA ...

Spliceosome-mediated RNA trans-splicing (SMaRT) is an emerging technology in which RNA pre-therapeutic molecules (PTMs) are designed to recode a specific pre-mRNA by suppressing cis-splicing while ...

More information: Yi Li et al, Structural insights into spliceosome fidelity: DHX35–GPATCH1- mediated rejection of aberrant splicing substrates, Cell Research (2025). DOI: 10.1038/s41422-025-01084-w ...

Tau-mediated RNA splicing errors linked to Alzheimer’s. Graciela Gutierrez. 713-798-4710. Houston, TX - Oct 8, 2019. Share this article. ... Minor perturbations in the assembly and/or function of the ...

Researchers at the Center for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome ...

Spliceosome-mediated RNA trans-splicing (SMaRT) -- gene reprogramming system designed to correct aberrantly spliced mRNAs by replacing the entire coding sequence upstream or downstream of a ...

Spliceosome-mediated RNA trans-splicing (SMaRT) - gene reprogramming system designed to correct aberrantly spliced mRNAs by replacing the entire coding sequence upstream or downstream of a splice ...

“We report transcriptome-wide analyses upon systematic knock down of 305 spliceosome components and regulators in human cancer cells and the reconstruction of functional splicing factor networks ...

Tau-mediated RNA splicing errors linked to Alzheimer's disease. Baylor College of Medicine. Journal Cell Reports DOI 10.1016/j.celrep.2019.08.104 ...

Spliceosome-mediated RNA trans-splicing (SMaRT) - gene reprogramming system designed to correct aberrantly spliced mRNAs by replacing the entire coding sequence upstream or downstream of a splice site ...