Tau-mediated RNA splicing errors linked to Alzheimer’s. Graciela Gutierrez. 713-798-4710. Houston, TX - Oct 8, 2019. Share this article. ... Minor perturbations in the assembly and/or function of the ...

What is the spliceosome? At the core of the splicing process is the spliceosome, a highly intricate molecular complex responsible for removing introns from pre-mRNA. 1 Composed of small nuclear RNA ...

Conventional gene therapy of hemophilia A relies on the transfer of factor VIII (FVIII; encoded by the F8 gene) cDNA. We carried out spliceosome-mediated RNA trans-splicing (SMaRT) to repair ...

Spliceosome-mediated RNA trans-splicing (SMaRT) -- gene reprogramming system designed to correct aberrantly spliced mRNAs by replacing the entire coding sequence upstream or downstream of a ...

More information: Yi Li et al, Structural insights into spliceosome fidelity: DHX35–GPATCH1- mediated rejection of aberrant splicing substrates, Cell Research (2025). DOI: 10.1038/s41422-025-01084-w ...

Spliceosome-mediated RNA trans-splicing (SMaRT) - gene reprogramming system designed to correct aberrantly spliced mRNAs by replacing the entire coding sequence upstream or downstream of a splice site ...

Spliceosome-mediated RNA trans-splicing (SMaRT) - gene reprogramming system designed to correct aberrantly spliced mRNAs by replacing the entire coding sequence upstream or downstream of a splice ...

Tau-mediated RNA splicing errors linked to Alzheimer's disease. Baylor College of Medicine. Journal Cell Reports DOI 10.1016/j.celrep.2019.08.104 ...

The two first major components of the spliceosome do not need to communicate with one another to start the splicing process, nor does it matter which piece attaches to the gene first. Either of the ...

Researchers at the Center for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome ...