Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...

Structural basis of 5′ splice site recognition by the minor spliceosome. Molecular Cell , 2025; 85 (3): 652 DOI: 10.1016/j.molcel.2024.12.017 Cite This Page : ...

EMBL Grenoble Group Leader Wojciech Galej, who has been working on pre-mRNA splicing machinery for more than 15 years, first decided to focus on the minor spliceosome seven years ago – a project ...

Researchers at the Center for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine inside every cell.

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

“We report transcriptome-wide analyses upon systematic knock down of 305 spliceosome components and regulators in human cancer cells and the reconstruction of functional splicing factor networks ...

Spliceosome-mediated RNA trans-splicing (SMaRT) - gene reprogramming system designed to correct aberrantly spliced mRNAs by replacing the entire coding sequence upstream or downstream of a splice ...

Transcriptome-wide splicing network reveals specialized regulatory functions of the core spliceosome. Science , 2024; 386 (6721): 551 DOI: 10.1126/science.adn8105 Cite This Page : ...

RNA splicing is a cellular process that is critical for gene expression. ... involving LUC7 proteins that influence spliceosome targeting of specific 5' splice sites.

During splicing, this transcript undergoes modification: a cellular editing complex, the spliceosome, removes certain segments. The outcome varies depending on which parts are cut out, resulting ...