A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

The spliceosome is critical for the proper functioning of every cell, and numerous genetic disorders are linked to problems with spliceosome function.

Spliceosome Structure And Function; ... The spliceosome is a dynamic macromolecular machine responsible for the precise excision of introns from pre-messenger RNA (pre-mRNA), ...

Transcriptome-wide splicing network reveals specialized regulatory functions of the core spliceosome. Science , 2024; 386 (6721): 551 DOI: 10.1126/science.adn8105 Cite This Page : ...

The scientists’ work revealed that different components of the spliceosome have unique regulatory functions. “Collectively, our results demonstrate how systematic, ...

The Galej Group at EMBL Grenoble has provided new insights into minor spliceosome function, revealing the structure of U11 snRNP – one of its subunits, ...

Discovery of how a key enzyme of the spliceosome exerts its controlling function Date: May 24, 2013 Source: Freie Universitaet Berlin Summary: To sustain life, processes in biological cells have ...

On the other hand, ∼ 20 nucleotides downstream of the 3′SS are likely embedded in the spliceosome, because Prp22 (an ATPase with splicing fidelity and disassembly functions) requires a segment ...

Team finds how a key enzyme of the spliceosome exerts its controlling function. by Freie Universitaet BerlinFreie Universitaet Berlin ...

The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps") – and about 150 proteins, involved in different stages ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...