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Understanding the Complex Architecture of the Minor Spliceosome
Jiangfeng Zhao, postdoctoral fellow in the Galej Group and the first author of the study Spliceosomes are large and dynamic RNA-protein complexes. The major spliceosome consists of five subunits ...
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The minor spliceosome: Researchers reveal new structural insights into an essential RNA-protein complex
Spliceosomes are large and dynamic RNA-protein complexes. The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps ...
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New Structural Insights Into the Minor Spliceosome
Spliceosomes are large and dynamic RNA-protein complexes. The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read “snurps”) – ...
Nature1y
Searching for a wrench to throw into the splicing machine
Furthermore, as with many macromolecular complexes taken out of their cellular environment, in vitro spliceosome activity is not overly efficient and thus assay sensitivity was another challenge.