When the Galej Group started the project, little was known about the minor spliceosome, and even now, only a handful of research groups are doing structural studies on this RNA-protein complex.

When the Galej Group started the project, little was known about the minor spliceosome, and even now, only a handful of research groups are doing structural studies on this RNA-protein complex.

Precursor messenger RNA splicing is catalyzed by the spliceosome, a macromolecular complex that assembles in a stepwise process. The spliceosome's dynamic nature suggests the potential for ...

Splicing twins: Unravelling the secrets of the minor spliceosome complex. European Molecular Biology Laboratory. Journal Molecular Cell DOI 10.1016/j.molcel.2024.12.017. Keywords ...

Splicing twins: Unraveling the secrets of the minor spliceosome complex. ScienceDaily. Retrieved June 9, 2025 from www.sciencedaily.com / releases / 2025 / 02 / 250212141347.htm.

B complex formation was inhibited in PRP28-depleted extract (lanes 7 and 8). In the presence of inhibitors, nonphosphorylated PRP28 could not alleviate this block (lane 9).

It is a complicated complex, made up of four major parts and more than 100 accessory proteins that come together and break apart throughout the splicing process. Think of the spliceosome as an old ...

Researchers at the Centre for Genomic Regulation (CRG) have created the first blueprint of the human spliceosome, the complex molecular machine that edits genetic messages transcribed from DNA, ...

Researchers at the Centre for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine in human biology.

After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA.

Researchers have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine in human biology. The vast majority of human genes -- more than nine in ten ...