When the Galej Group started the project, little was known about the minor spliceosome, and even now, only a handful of research groups are doing structural studies on this RNA-protein complex.

When the Galej Group started the project, little was known about the minor spliceosome, and even now, only a handful of research groups are doing structural studies on this RNA-protein complex.

Splicing twins: Unravelling the secrets of the minor spliceosome complex. European Molecular Biology Laboratory. Journal Molecular Cell DOI 10.1016/j.molcel.2024.12.017. Keywords ...

A specialized molecular complex known as the minor spliceosome removes some rare but critical introns, and several genetic disorders are associated with its dysfunction.

“The spliceosome is the complex molecular machinery that sequentially assembles on eukaryotic messenger RNA precursors to remove introns (pre-mRNA splicing), a physiologically regulated process ...

The spliceosome complex removes intron sequences from RNA transcripts to form messenger RNA. The structure of a spliceosomal protein, Prp8, reveals the complex's active site and casts light on the ...

Researchers have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine in human biology. The vast majority of human genes -- more than nine in ten ...

The spliceosome complex was found to be interconnected, with disruptions in one portion having significant effects on other parts of the complex. "Their reliance on a highly interconnected splicing ...

The spliceosome: An atomic-level look into how cells avoid errors when manufacturing mRNA. A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after ...

The spliceosome is best known for shepherding primary messenger RNA transcripts to maturity. This enzyme complex also contributes to the synthesis of an enzyme that maintains chromosome ends.

Researchers at the Centre for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine in human biology.