The spliceosome then converts them into mature, functional mRNA. To do this, this large protein-RNA complex, which is located ...

The results have appeared under the title 'Xrp1 governs the stress response program to spliceosome dysfunction' in Nucleic Acids Research. All eukaryotes (i.e. organisms in which DNA is enclosed ...

Structures of aberrant spliceosome intermediates on their way to disassembly. Nature Structural & Molecular Biology , 2025; DOI: 10.1038/s41594-024-01480-7 Cite This Page : ...

The Galej Group at EMBL Grenoble has recently published new structural insights into minor spliceosome function in the journal Molecular Cell. Read the full story here .

A new study found that aged neurons have defects in key proteins that make them vulnerable to molecular stress and neurodegenerative damage. ... especially spliceosome components.” ...

Romancing the Spliceosome to Fight Spinal Muscular Atrophy. ... such as stress or cellular injury. 2,3 Identifying small molecules that modify splicing and in turn alter the quantity or ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...