A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA.

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA.

During splicing, this transcript undergoes modification: a cellular editing complex, the spliceosome, removes certain segments. The outcome varies depending on which parts are cut out, resulting ...

“Understanding why this is the case, understanding how these fluctuations in temperature are sensed and how those signals are transduced into sort of spliceosome function is certainly something that's ...

a spliceosome component, as well as RNA helicase, and immortalization-upregulated nuclear proteins. Antibody production using cDNA immunization: When an expression vector carrying human full-length ...

Y14 — a protein that binds RNA in a spliceosome-dependent manner and ... the mRNA was cleaved in a sequence-specific manner. An anti-Y14 antibody was then used to show that only specific RNA ...

Structural biologists provide a first-time look at the atomic level into the quality control mechanism of this complex molecular machine A complex molecular machine, the spliceosome, ensures that ...