The spliceosome: An atomic-level look into how cells avoid errors when manufacturing mRNA
A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...
The minor spliceosome: Researchers reveal new structural insights into an essential RNA-protein complex
In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell ...
How Cells Avoid Errors When Manufacturing mRNA
A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...
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Genes spatially organize for efficient mRNA splicing, study shows
More information: Prashant Bhat et al, Genome organization around nuclear speckles drives mRNA splicing efficiency, Nature (2024). DOI: 10.1038/s41586-024-07429-6 Provided by California Institute ...
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Spliceosome: Cells' Error-Free MRNA Production Explained
A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...
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Understanding the Complex Architecture of the Minor Spliceosome
In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell ...
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All About Alternative Splicing
Research into splicing mechanisms and patterns is essential for decerning fundamental biological principles, as well as clarifying the molecular basis of many diseases and developing new therapies. 2 ...
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Gene Proximity to Nuclear Speckles Drives Efficient mRNA Splicing
In a recent article, he showed that when genes are preferentially positioned near speckles, mRNA splicing is significantly more efficient. 4 “It’s huge for the RNA processing field, because now it ...
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Risdiplam Tablet for Spinal Muscular Atrophy Receives FDA Approval
The 5 mg risdiplam tablet provides the same efficacy and safety for spinal muscular atrophy as the currently available oral ...
EurekAlert!8d
Deciphering the regulatory programs of RNA binding proteins in rheumatoid arthritis through single-cell transcriptome analysis
Announcing a new publication for Acta Materia Medica journal. Single-cell RNA sequencing (scRNA-seq) data from published datasets were obtained to investigate the expression and dysregulation of ...
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Dysregulation of RNA-binding proteins in rheumatoid arthritis and osteoarthritis
Announcing a new publication for Acta Materia Medica journal. Single-cell RNA sequencing (scRNA-seq) data from published datasets were obtained to investigate the expression and dysregulation of ...