They have an enlarged spleen. They may even have some degree ... 42 had stable or improved fibrosis, including eight patients who had resolution bone marrow fibrosis after 48 weeks.

Fibrosis is a leading cause of death and disability ... leading to severe anemia, an enlarged spleen, clotting disorders, and hemolytic complications that can lead to death within several years ...

It is designed to evaluate key endpoints including bone marrow fibrosis reduction, spleen volume reduction (SVR), and improvement in total symptom score (TSS). The decision to proceed with this ...