The discovery of the RNA self-splicing group I intron provided the first demonstration that not all enzymes are proteins. Here we report the X-ray crystal structure (3.1-Å resolution) of a ...

A team led by Prof. ZHANG Kaiming from the University of Science and Technology (USTC) solved six conformations in the second-step self-splicing of Tetrahymena ribozyme using cryogenic electron ...

RNA splicing ribozymes have been shown to possess a conserved active site that can engage small ... the self-splicing group II introns, the bacterial and organellar ancestors of the nuclear ...

Visualizing the machinery of mRNA splicing Date: April 8, 2008 Source: Yale University Summary: Recent research at Yale provided a glimpse of the ancient mechanism that helped diversify our ...

RNA controls splicing during gene expression, ... The researchers first disabled the ability of the spliceosome to self-correct errors in splicing.

Inserting self-splicing introns enabled gene editing at multiple locations simultaneously in orthogonal ribosomes, the messenger RNA binding site (green) in the small subunit (beige) and the ...

Because the chemical mechanism for splicing is very similar between the spliceosomes and their distant cousins, the Group II introns, many researchers have theorized that when the process of ...

University of Zurich scientists demonstrated that they could reassemble and express large genes using a new dual adeno-associated viral (AAV) vector technology that depends on mRNA trans-splicing ...