This step occurs by transesterification ... without disrupting the function of the old gene. Our knowledge of RNA splicing is quite new. Nonetheless, because nearly all eukaryotes have introns ...

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

RNA splicing is a cellular process that is critical ... and noncoding RNAs called small nuclear RNAs (snRNAs). In the first step of spliceosome assembly, an snRNA molecule known as U1 snRNA ...

What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms.

This enzyme helps newly built spliceosomes get themselves into shape for RNA splicing. Next ... the regulator protein is needed for an earlier step in spliceosome assembly.

Alternative RNA splicing is like a movie editor cutting and rearranging scenes from the same footage to create different versions of a film.

RBP splicing factors are sequence-specific, binding to their cognate sequence motifs like a lock and key. “Because the binding pocket of the RBP matches the sequence motif, the RBP binds to the ...

RNA splicing is a cellular process that is critical ... and noncoding RNAs called small nuclear RNAs (snRNAs). In the first step of spliceosome assembly, an snRNA molecule known as U1 snRNA ...

RNA sequencing has emerged as a powerful supplement to DNA sequencing for Mendelian disease diagnosis, but clinical translation of diagnostic RNA-seq has not been widely achieved. Researchers at ...