Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

a brain region significantly impacted by HD-related neuronal dysfunction. "By targeting key processes like RNA splicing and modification, we not only advance our understanding of the molecular ...

RBP splicing factors are sequence-specific, binding to their cognate sequence motifs like a lock and key. “Because the binding pocket of the RBP matches the sequence motif, the RBP binds to the ...

such as splicing. However, testing these functions directly has been challenging due to the complexity of RNA processing ...

Within the cell, NOVA1’s job is to bind to RNA to regulate alternative splicing ... However, when they compared alternative splicing events in the periaqueductal gray, a midbrain region which is a key ...