Spliceosomes are large and dynamic RNA-protein complexes. The major spliceosome consists of ... a dozen other steps are needed before the splicing reaction concludes. Not much is known about ...

Proper splicing requires efficient spliceosome assembly. Here the authors reveal that zinc finger protein 207 interacts with the U1 small nuclear ribonucleoprotein to accelerate spliceosome ...

Ultimately, the spliced messenger RNA consists of only protein-encoding exons. Splicing is catalyzed by a large molecular machine. This spliceosome is made up of variety of protein and RNA components, ...

The process of RNA splicing by the spliceosome helps to generate molecular diversity beyond the genome sequence. In the May 3 Science, Tyson Clark and colleagues at the University of California, Santa ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

Then the RNA binding protein communicates to the splicing machinery to include or not include the exon into the mRNA,” Cooper explained. The fit between a splice site and the spliceosome components ...

Spliceosomes are large and dynamic RNA-protein complexes. The major spliceosome consists of five subunits ... At least a dozen other steps are needed before the splicing reaction concludes. Not much ...

Ultimately, the spliced messenger RNA consists of only protein-encoding exons. Splicing is catalyzed by a large molecular machine. This spliceosome is made up of variety of protein and RNA ...

Jiangfeng Zhao, postdoctoral fellow in the Galej Group and the first author of the study Spliceosomes are large and dynamic RNA-protein complexes. The major spliceosome consists of five subunits ...

Varvara Dikaya's research sheds light on an essential part of this puzzle: RNA splicing, a process that ... this protein is part of the spliceosome, a molecular complex that modifies RNA before ...

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...