Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

“Because the binding pocket of the RBP matches the sequence motif, the RBP binds to the specific set of several nucleotides. Then the RNA binding protein ... mediated decay (NMD) is a process closely ...

RNA splicing, a process discovered in the late 1970s ... allowing the cell to assemble the correct sequence for a desired ...

The pre-mRNA molecule thus goes through a modification process in the nucleus called splicing ... RNA molecule that is then translated into a protein. Introns are also referred to as intervening ...

RNA splicing, a process discovered in the late 1970s ... allowing the cell to assemble the correct sequence for a desired ...

As its name suggests, splicing involves snipping out certain sequences in the RNA ... introduced during this splicing process. Biogen has been involved in RNA splicing research since its earliest ...

This process is known as splicing. Ultimately, the spliced messenger RNA consists of only protein-encoding exons. Splicing is catalyzed by a large molecular machine. This spliceosome is made up of ...

RNA (ribonucleic ... nucleotide bases. Trans-splicing enables the ligation of exons from different pre-mRNAs into a single transcript. A recent study harnesses this process and develops ...

Alternative RNA splicing is similar to a movie editor cutting and rearranging scenes from the same video to produce distinct versions of a film. By deciding which sequences to keep and which to ...