Overview of RNA repair – There is an emerging appreciation of the existence of “RNA repair” pathways that rely on RNA ligases to maintain or manipulate RNA structure in response to purposeful RNA ...

C2H2 zinc finger proteins are the largest group of DNA-binding factors for transcription—the process of copying genetic ...

Trypanosomes are parasites that cause sleeping sickness, Chagas disease, and various animal diseases. Diagnosis and treatment remain complex and no effective vaccine has been developed. A better ...

Researchers studying gene expression have access to vast amounts of data from cells or tissues. This is thanks to advances in ...

This study not only discovered a novel 3′ UTR-derived sRNA but also expanded the understanding of RNase III-mediated RNA processing. It highlights the critical role of ManNAc in bacterial ...

Understanding RNA Processing Kinetoplastids have helped scientists understand RNA processing events, such as RNA editing. To date, gene expression resulting from RNA editing has been described in ...

which binds to specific promoter regions on the DNA and initiates the synthesis of the complementary RNA strand. The resulting primary transcript, known as pre-mRNA in eukaryotes, undergoes several ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

Several mechanisms have evolved that regulate the biogenesis of specific classes of small RNA using variations on the same core processing machinery. Most animals encode a single Dicer protein ...

Antibody-RNA Conjugates represent a significant advancement in the treatment of challenging and rare diseases with unmet medical need.

These factors use the cap-binding complex as a platform to lead the RNA to its next processing step or to a new location in the cell. Unlike its human counterpart, which has two sub-units ...