In the microscopic world of bacteria, gene transfer is a powerful mechanism that can alter cellular function, drive antibiotic resistance and even ...

For example, many types of RNA have been found to be catalytic--that is, they carry out biochemical reactions just like enzymes do. Furthermore, many other varieties of RNA have been found to have ...

RNA abundance is regulated by balancing transcription and degradation in processes that control the temporal and spatial distribution of cellular RNA. In eukaryotic cells, mRNA decay is catalyzed by ...

This discovery led to the concept of the ribosome as a ribozyme, an RNA molecule with enzymatic properties. The catalytic center of the ribosome, known as the peptidyl transferase center (PTC), is ...

Some RNA molecules, called ribozymes, possess catalytic activity and can catalyze chemical reactions. For example, the ribosome itself is a ribozyme, as the rRNA component catalyzes the formation of ...

Rnl1 then joins the 3’-OH and 5’-PO 4 RNA ends. We have probed in depth the structural basis for catalysis by T4 Pnkp and Rnl1 and the features of the PrrC anticodon nuclease that are required for ...

Studies suggest that naturally occurring SAM-binding RNA could be derived from earlier ribozymes that lost their catalytic function during evolution," says Höbartner. Knowledge of the structure ...

Gene expression is linked to RNA transcription, which cannot happen without RNA polymerase. However, this is where the similarities between prokaryote and eukaryote expression end. Central to the ...

We are also exploring novel methods for the detection of residual dipolar couplings (RDCs) which assist in determining the correct global structure of an RNA. Ribozymes are catalytic RNAs that perform ...