The spliceosome: An atomic-level look into how cells avoid errors when manufacturing mRNA
A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...
Hosted on MSN2mon
Slow editing of protein blueprints leads to cell death, spliceosome study discovers
Their findings reveal that spliceosome subunits U4, U5 and U6 are normally stabilized as a complex by a protein called USP39. However, when subunits are mutated or USP39 is absent, the stability ...
EurekAlert!4d
Spliceosome: How cells avoid errors when manufacturing mRNA
The spliceosome then converts them into mature, functional mRNA. To do this, this large protein-RNA complex, which is located in the cell nucleus, removes non-coding sections (introns) from mRNA ...
The Scientist4mon
All About Alternative Splicing
Then the RNA binding protein communicates to the splicing machinery to include or not include the exon into the mRNA,” Cooper explained. The fit between a splice site and the spliceosome components ...
Baylor College of Medicine22d
Circular RNAs: Unexpected outputs of protein-coding genes
Surprisingly, when spliceosome components were depleted or inhibited pharmacologically ... of canonical pre-mRNA processing events shifts the steady-state output of protein-coding genes towards ...