Unlike nitroglycerin, which improves vasodilation but blunts the inotropic effects of therapeutic drugs such as dobutamine, the nitroxyl anion, with one less electron than nitric oxide, appears to ...

A novel nanomedicine technology can deliver protective nitroxyl radical-containing nanoparticles following oxidative stress injury, such as occur in stroke and cerebral ischemia-reperfusion.

Nitroxyl (HNO): A reactive nitrogen species derived from nitric oxide by a one-electron reduction and protonation process, notable for its distinct reactivity with thiols and metal centres.

Patients with advanced HF who were treated with a novel nitroxyl donor had improved cardiac performance, according to a study published in the European Journal of Heart Failure. In this randomized ...

New Method For Detecting Nitroxyl Will Boost Cardiac Drug Research Date: August 3, 2009 Source: Wake Forest University Summary: Scientists have developed a new research tool in the pursuit of ...

Nitroxyl, a cousin to the blood-vessel relaxing compound nitric oxide, has been shown in studies to strengthen canine heart beats, but research into its potential benefits for humans has been ...

BMS-986231 (Bristol-Myers Squibb/Ligand) Drug Overview 2018: A Second-Generation Prodrug That Chemically Breaks Down to Produce Nitroxyl (HNO) and an Inactive Byproduct - ResearchAndMarkets.com ...

Unique chemical markers for detecting the presence of a compound called nitroxyl in biological systems have been identified by Wake Forest University scientists. This achievement can boost cardiac ...

Since 2016, a group of scientists at Russia’s St. Petersburg University has investigated a group of materials known as redox-active nitroxyl-containing polymers.

Nitroxyl is formed in cells, and drugs are currently in development that release it to help prevent heart failure. However, little is currently known about how exactly the molecule works, and why it ...