The more recently solved 3D structures of the PCAF and CBP bromodomains bound to lysine-acetylated histone H3 and H4 peptides provide important new insights into the structural and molecular bases ...

These incisive chemical probes have availed new insights into chromatin structure and function, and suggest plausible translational opportunities for the targeted development of drug-like derivatives ...

The most recently discovered amino acid, pyrrolysine, is produced by a series of just three chemical reactions with a single precursor -- the amino acid lysine, according to new research.

New research in yeast cells may have pinpointed a key enzyme in the molecular circuitry that silences genes. ... By methylating H3 at lysine 4, Set7 makes the chromatin structure more open, ...

Researchers from Osaka University have found that the attachment of a ubiquitin molecule to a protein called PCNA at the lysine 107 position causes gross chromosomal rearrangements. This lysine is ...

Proteins are formed in cells by linking amino acid building blocks together in a defined sequence. There are 20 different amino acids that are used to build proteins, including cysteine and lysine ...

Dublin, April 22, 2024 (GLOBE NEWSWIRE) -- The "Lysine specific demethylase 1 inhibitors - Pipeline Insight, 2024" clinical trials has been added to ResearchAndMarkets.com's offering.This "Lysine ...

Using cryo-electron microscopy, which enables visualization of frozen molecular structures at high resolution, the team analyzed this unique complex at a resolution of 3.66 Å ...