The minor spliceosome has a similar architecture, but its main building blocks are different (U11, U12, U4atac, U6atac, and U5 snRNPs).

When the Galej Group started the project, little was known about the minor spliceosome, and even now, only a handful of research groups are doing structural studies on this RNA-protein complex.

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

The Galej Group at EMBL Grenoble has provided new insights into minor spliceosome function, revealing the structure of U11 snRNP – one of its subunits, ...

When the Galej Group started the project, little was known about the minor spliceosome, and even now, only a handful of research groups are doing structural studies on this RNA-protein complex.

When the Galej Group started the project, little was known about the minor spliceosome, and even now, only a handful of research groups are doing structural studies on this RNA-protein complex.

When minor spliceosome activity is reduced, the minor introns are retained in the mRNA while the major introns are spliced out. This signals the mRNA for degradation, limiting the expression of ...

Our new paper in the EMBO Journal links minor spliceosome to chromosome segregation. We identified the CCDC84/CENATAC protein as a novel component of the minor spliceosome. It has a striking ...

With each type of spliceosome recognizing different splicing cues, the major spliceosome acts on the vast majority of introns (>200,000) and the minor one splices the several hundred minor-type ...

Researchers explored the role of the minor intron-containing gene (MIG)-encoded proteins (MIG-Ps) depending on minor spliceosome-MiG excision to be expressed in infections by pathogenic viruses.

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...