In this study, the researchers reveal the structure of U11 snRNP—one of the five subunits of the minor spliceosome, which initiates the intron selection process. Spliceosomes help cells remove ...

In this new study, the researchers reveal the structure of U11 snRNP – one of the five subunits of the minor spliceosome, which initiates the intron selection process. Spliceosomes help cells remove ...

In this new study, the researchers reveal the structure of U11 snRNP – one of the five subunits of the minor spliceosome, which initiates the intron selection process. Spliceosomes help cells ...

With the participation of U5, the 3′ end of the intron is brought into proximity, cut, and joined to the 5′ end. This step occurs by transesterification; in this case, an OH group at the 3 ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

The spliceosome (not shown) was known to catalyze two chemical reactions (black arrows) in a two-step process (green arrows labeled 1 and 2) that splice the exons together and removes the intron ...