Investigation of the electrophoretic characteristics of NADH methemoglobin reductase in five unrelated families with a deficiency of this enzyme showed three different types of enzyme patterns: tot ...

The NADH methemoglobin reductase was assayed in all eight subjects by the method of Scott, 11 which measures the ability of hemolysate to reduce the dye dichlorobenzenoneindophenol.

A report published in the New England Journal of Medicine describes the case of a 25-year-old woman who developed methemoglobinemia following the use of topical benzocaine.

The Fugates probably had a deficiency in the enzyme called cytochrome-b5 methemoglobin reductase, which is responsible for recessive congenital methemoglobinemia.

According to ABC News, the Fugates most likely suffered from a deficiency in the enzyme known as cytochrome-b5 methemoglobin reductase, which causes recessive congenital methemoglobinemia.

A study comparing the relative ability of benzocaine and lidocaine to make methemoglobin showed that benzocaine generated much more methemoglobin than lidocaine in a red blood cell model.

The FDA has issued a public health advisory regarding inappropriate use of benzocaine topical sprays and risk factors for methemoglobinemia.

The main treatment for methemoglobinemia is methylene blue, which works as a cofactor for the NADPH methemoglobin reductase enzyme system to produce leukomethylene blue, which allows for the ...

Methylene blue acts as a co-factor for nicotinamide adenine dinucleotide phosphate (NADPH)-dependent methemoglobin reductase, which leads to the formation of reduced methylthioninium chloride that ...

Furthermore newborns seem to be at a higher risk of developing methemoglobinemia due to a lower level of methemoglobin reductase and the fact that foetal haemoglobin is more easily oxidized.