Methylene blue acts as a co-factor for nicotinamide adenine dinucleotide phosphate (NADPH)-dependent methemoglobin reductase, which leads to the formation of reduced methylthioninium chloride that ...

Cyanosis was noted at birth, and at 9 hours she had 5.8 gm. of methemoglobin per 100 ml. (33 per cent of total hemoglobin). A single administration of methylene blue (0.8 ml. of 1 per cent ...