When the researchers ran flow cytometry on the atypical Ly6G + cells collected ... They found that Ly6G + macrophages repair the lungs and liver of mice after drug-induced injuries as well. The team ...

and vascular remodeling that makes vessels resistant to blood flow. This forces the heart to work harder." Kourembanas ...

This dysfunction resulted in disruption of the macrophage’s ability to function properly, leading to persistent inflammation and lung scarring, key contributors to long COVID symptoms.

More information: Emily M. King et al, Gpnmb and Spp1 mark a conserved macrophage injury response masking fibrosis-specific programming in the lung, JCI Insight (2024). DOI: 10.1172/jci.insight.182700 ...