A new technology to improve the efficacy and safety of gene therapy drugs was developed. A transient, selective, and safe coating of the liver sinusoidal wall was achieved. As a result, the ...

In a breakthrough that brings bioengineered organs one step closer to reality, scientists have created lab-grown liver tissue capable of forming its own blood vessels. A team from Cincinnati ...

To make their liver-sinusoid model, Sun and colleagues first used standard soft lithography to fabricate a dimethylsiloxane (PDMS) chip with three chambers. Two kinds of natural collagen – one laden ...

A team of researchers have created a 'liver on a chip,' a model of liver tissue that replicates the metabolic variations found throughout the organ and more accurately reflects the distinctive ...

Similar differences for other liver functions are well known, with metabolic changes occurring across the 25-cell length of the sinusoid.

Scientists from Cincinnati Children's and colleagues based in Japan report achieving a major step forward in organoid technology: producing liver tissue that grows its own internal blood vessels.

Utilizing the PhaseGuide™ technology we are able to engineer our culture to mimic the structure of the liver sinusoid by culturing hepatocyte and stellate cells in an extracellular matrix protein gel, ...

Newcells’ sinusoid model will be constructed entirely from liver cell types generated from hepatocytes and endothelial cells, in addition to those cells of the immune system typically resident in or ...

The NIH has awarded MIMETAS and the University of Pittsburgh a prestigious SBIR grant to develop a Liver-on-a-Chip platform for high throughput discovery and development. Accurate prediction of ...