the 3′ end of the intron is brought into proximity, cut, and joined to the 5′ end. This step occurs by transesterification; in this case, an OH group at the 3′ end of the exon attacks the ph ...
In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell ...
The vast majority of introns are removed by the major spliceosome ... 3'-OH of the upstream exon attacks the 3' splice site phosphodiester to liberate the lariat intron and join (ligate) the ...
AZoLifeSciences on MSN19h
Understanding the Complex Architecture of the Minor SpliceosomeIn human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell ...
The spliceosome (not shown) was known to catalyze two chemical reactions (black arrows) in a two-step process (green arrows labeled 1 and 2) that splice the exons together and removes the intron ...
Surprisingly, when spliceosome components were depleted or ... We propose that this is because cross-exon interactions are not easily replaced with cross-intron interactions, thereby causing ...
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