Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...

Spliceosomal introns are thought to have had a central role in shaping modern genomes. Recent studies have shed new light on the timing of intron evolution, mechanisms of intron loss and gain, and ...

However, the U2AF 35 –AG interaction early in spliceosome assembly is just the beginning of a complex process by which the eventual site of exon ligation is determined. The molecular details of ...

The spliceosome does the genetic cutting and pasting. ... To initiate the splicing process, two pieces of the spliceosome bind to the two ends of an intron. Until now, scientists believed this to be ...

However, when knocking down snRNAs in MCF-7 cells (breast cancer cells), most splicing changes affected only one exon. Intron retention was limited to knockdown of some of the snRNAs, but not all of ...

In this study, the researchers reveal the structure of U11 snRNP—one of the five subunits of the minor spliceosome, which initiates the intron selection process. Stitching gene pieces together.

In this new study, the researchers reveal the structure of U11 snRNP – one of the five subunits of the minor spliceosome, which initiates the intron selection process. Stitching gene pieces together ...

In this new study, the researchers reveal the structure of U11 snRNP -- one of the five subunits of the minor spliceosome, which initiates the intron selection process. Stitching gene pieces together ...

Now that Ares and his lab have shown that the spliceosome has the catalytic ability to hypothetically place introns back into DNA like their ancestors did, the next step is for the researchers to ...

If the spliceosome is able to reinsert the intron into DNA, this would also add significant weight to the theory that spliceosomes and Group II introns shared a common ancestor long ago.

Researchers explored the role of the minor intron-containing gene (MIG)-encoded proteins (MIG-Ps) depending on minor spliceosome-MiG excision to be expressed in infections by pathogenic viruses.

The spliceosome does the genetic cutting and pasting. It is a complicated complex, made up of four major parts and more than 100 accessory proteins that come together and break apart throughout ...