This step occurs by transesterification; in this case, an OH group at the 3′ end of the exon ... of RNA splicing, splicing itself must be quite ancient. Proponents of the "intron-early" theory ...

Human genes that encode proteins often contain non-coding segments known as introns. Removing introns is crucial for the proper expression of genetic information. Understanding how our cells ...

They can also be within the exon.” RBP splicing factors are sequence-specific, binding to their cognate sequence motifs like a lock and key. “Because the binding pocket of the RBP matches the sequence ...

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Alternative splicing (AS), a critical process for gene expression regulation, allows a single precursor ...

Alternative splicing promotes adaptation to environmental changes; in fungi, the most common example of alternative splicing is intron retention. To explore the relationship between splicing and ...

“Our work provides exciting new insights into the mechanism of minor intron recognition and sheds light on the evolution of the splicing machinery. It opens up new possibilities for studying other ...

"Our work provides exciting new insights into the mechanism of minor intron recognition and sheds light on the evolution of the splicing machinery. It opens up new possibilities for studying other ...

A self-described “classic nerd,” Tomberg began running some experiments of her own to try “to figure out what makes an intron from ... that indicate good splicing and bad splicing.