This step occurs by transesterification; in this case, an OH group at the 3′ end of the exon ... of RNA splicing, splicing itself must be quite ancient. Proponents of the "intron-early" theory ...

We therefore discarded any cases of whole-intron retention (although ... had unequivocal alternative splicing events, with cryptic exons, 5′ exon extensions and 3′ exon extensions occurring ...

They can also be within the exon.” RBP splicing factors are sequence-specific, binding to their cognate sequence motifs like a lock and key. “Because the binding pocket of the RBP matches the sequence ...

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

Alternative splicing (AS), a critical process for gene expression regulation, allows a single precursor RNA to produce multiple transcript variants. Alterations in exon exclusion, intron retention ...