This step occurs by transesterification; in this case, an OH group at the 3′ end of the exon ... of RNA splicing, splicing itself must be quite ancient. Proponents of the "intron-early" theory ...

Human genes that encode proteins often contain non-coding segments known as introns. Removing introns is crucial for the proper expression of genetic information. Understanding how our cells ...

They can also be within the exon.” RBP splicing factors are sequence-specific, binding to their cognate sequence motifs like a lock and key. “Because the binding pocket of the RBP matches the sequence ...

Alternative splicing promotes adaptation to environmental changes; in fungi, the most common example of alternative splicing is intron retention. To explore the relationship between splicing and ...

Stargardt disease type 1 (STGD1) is an inherited retinal recessive disease caused by biallelic variants in the ABCA4 gene. One of the recurrent variants is located at the exon-intron junction of exon ...

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