splicing itself must be quite ancient. Proponents of the "intron-early" theory suggest that all organisms (including prokaryotes) at one time had introns in their genome but subsequently lost ...

"Our work provides exciting new insights into the mechanism of minor intron recognition and sheds light on the evolution of the splicing machinery. It opens up new possibilities for studying other ...

In the first step of spliceosome assembly, an snRNA molecule known as U1 snRNA binds to the 5' splice site at the beginning of the intron. Until now, it had been thought that the binding strength ...

The pre-mRNA molecule thus goes through a modification process in the nucleus called splicing during which the noncoding introns are cut out and only the coding exons remain. Splicing produces a ...

A pioneering study has uncovered the sophisticated tactics root-knot nematodes use to manipulate the genetic machinery of ...

Using biochemistry and cryo-electron microscopy, the researchers obtained the structure of the U11 snRNP complex and revealed how it recognises the “5’ splice site” – the starting point of an intron – ...

In the first step of spliceosome assembly, an snRNA molecule known as U1 snRNA binds to the 5' splice site at the beginning of the intron. Until now, it had been thought that the binding strength ...

Stay up to date on the latest science with Brush Up Summaries. Despite its significance, alternative splicing’s global impact on cellular homeostasis and intricate molecular mechanisms remains ...