Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...

In this study, the researchers reveal the structure of U11 snRNP—one of the five subunits of the minor spliceosome, which initiates the intron selection process. Stitching gene pieces together ...

Biologists have discovered a new type of RNA-splicing regulation that helps to determine which ... an snRNA molecule known as U1 snRNA binds to the 5' splice site at the beginning of the intron.

During splicing, the spliceosome assembles on the pre-mRNA molecule and brings together the donor site at the 5' end of the intron and the acceptor site at the 3' end of the intron. The intron is then ...

All the latest science news on intron from Phys.org. Find the latest news, advancements, and breakthroughs. Topics. ... The well-known essential pre-mRNA splicing factor U2AF heterodimer ...

Alternative splicing promotes adaptation to environmental changes; in fungi, the most common example of alternative splicing is intron retention. To explore the relationship between splicing and ...

First, the donor site is cleaved, and the 5' end of the intron is joined to a branch site within the intron, forming a looped structure called a lariat. Then, the free 3' end of the upstream exon is ...

"Our algorithm attempts to recognize these donor/acceptor sites in pairs, just as a spliceosome 'molecular machine' does in the cell when it cuts out an intron," says Chao. The researchers developed ...

Pre-tRNA is converted into mature tRNA, which has a complex 3D structure, through a series of steps, including the excision of an intron by specific endonucleases. In humans, this is catalyzed by the ...

During pre-mRNA transcription by Pol II, the spliceosome catalyzes two transesterification reactions along the RNA molecule, cleaving it twice and covalently joining adjacent exons, effectively ...