Determining the exact cause of the behavioural abnormalities, which may result from the motor deficits, will require extended analysis; however, the severe neurofibrillary pathology in the basal ...

Once amyloid pathology is underway, it predicts intracellular accumulation of hyperphosphorylated tau as neurofibrillary tangles and that, in turn, predicts onset of cognitive impairment.

The brains of patients with Alzheimer's disease are characterized by the abundance of extracellular amyloid plaques and intracellular neurofibrillary tangles. The major constituent of the amyloid ...

In neurodegenerative disorders, chemical changes in the brain cause tau proteins to detach and start to clump together, forming what are known as neurofibrillary tangles. These tangles disrupt the ...