Human genes that encode proteins often contain non-coding segments known as introns. Removing introns is crucial for the proper expression of genetic information. Understanding how our cells ...

A critical finding regarding the prevalence of alternative splicing was that a majority of human genes produce a wide variety of messenger RNAs (mRNA) that in turn encode distinct proteins ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell ...

Like a complex library in a tiny space 50 times smaller than the width of a human hair ... transcribed genes are in close proximity to speckles, enabling more efficient splicing.

Content More than 95 percent of human genes undergo alternative splicing and >50 percent of genes use alternative polyadenylation sites. For many genes, pre-mRNA processing directs expression of ...

By comparing human, mouse, zebrafish, and Fugu genomes, Burge's group discovered that intronic splicing enhancers appear to differ substantially between mammals and fish.1 By applying a scoring method ...

Alternative splicing is crucial for eukaryotic gene expression and influences protein function and regulation, with mis-splicing linked to numerous diseases. In this webinar, Dr. Megan L Noonan will ...

Boehringer will leverage ExpressionEdits' Genetic Syntax Engine which generates optimized introns to increase protein expression.