The spliceosome edits genetic messages transcribed from DNA, allowing cells to create different versions of a protein from a ...

RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, ...

Alternative splicing in human genes is widely viewed as a mechanism for enhancing proteomic diversity, the authors explained. During alternative splicing, different segments of genes are removed ...

The study, "Global impact of unproductive splicing on human gene expression levels and traits," was supported by funding from the National Institutes of Health (grants R01GM130738, R01HG011067 ...

The team at the CRG altered the expression of 305 spliceosome-related genes in human cancer cells one by one, observing the effects on splicing across the entire genome.

To explore the functional implications of human NOVA1, researchers used CRISPR gene editing to create mice that expressed the uniquely human version of this protein.Within the cell, NOVA1’s job is to ...

One familiar application of genome annotation is in genetic testing services, such as those offered by companies like 23andMe. These tests analyze parts of your genome to tell you about your ancestry, ...

The vast majority of human genes – more than nine in ten – are edited by the spliceosome. ... While humans have about 20,000 protein-coding genes, splicing allows the production of at least five times ...

This regulation affects about half of human genes and is present in animals and plants. LUC7 proteins interact with "right-handed" and "left-handed" splice sites, adding complexity to splicing.