Although DNA is a long, stringy molecule, in living cells it is folded and looped like a ball of yarn. This means that genes can be physically close to the “enhancer” DNA switches that turn them on ...

Enhancers can be thousands of nucleotides away from the promoters with which they interact, but they are brought into proximity by the looping of DNA. This looping is the result of interactions ...

Two new studies uncover how DNA folding controls sperm cell development. Researchers identified proteins that rearrange genomic architecture, setting cellular memory and fate.

Transcriptional enhancers are short regions of DNA that, when bound by proteins, increase the likelihood that a particular gene will be transcribed. They are therefore essential for controlling gene ...

Researchers used powerful technology to analyse thousands of individual cells at once, considering which genes are active.

This means that genes can be physically close to the "enhancer" DNA switches that turn them on and off even if they are far apart in the DNA sequence. To understand how genes are turned on and off ...

Although DNA is a long, stringy molecule, in living cells it is folded and looped like a ball of yarn. This means that genes can be physically close to the "enhancer" DNA switches that turn them ...

After TFs bind to promoter or enhancer regions of the DNA, they interact with other bound TFs and recruit RNA polymerase II. Their influence, however, can be either positive or negative ...

Although DNA is a long, stringy molecule, in living cells it is folded and looped like a ball of yarn. This means that genes can be physically close to the “enhancer” DNA switches that turn ...