Two new studies uncover how DNA folding controls sperm cell development. Researchers identified proteins that rearrange genomic architecture, setting cellular memory and fate.

Enhancers can be thousands of nucleotides away from the promoters with which they interact, but they are brought into proximity by the looping of DNA. This looping is the result of interactions ...

Enhancers were formerly believed to be modular. Each enhancer occupies a separate region of DNA, as the term suggests. “We have shown, however, that this is not absolutely true," explained ...

Transcriptional enhancers are short regions of DNA that, when bound by proteins, increase the likelihood that a particular gene will be transcribed. They are therefore essential for controlling gene ...

“We didn’t think it would work.” The results serve as an extreme example of what scientists are now recognizing as trends among enhancers—that activity can be conserved over long evolutionary ...

Researchers used powerful technology to analyse thousands of individual cells at once, considering which genes are active.

Although DNA is a long, stringy molecule, in living cells it is folded and looped like a ball of yarn. This means that genes can be physically close to the "enhancer" DNA switches that turn them on ...

New study by Chiba University, Japan in collaboration with Karolinska Institutet, Sweden, uncovers novel enhancer-promoter ... nucleotide position in the DNA—have been associated with ...

Although DNA is a long, stringy molecule, in living cells it is folded and looped like a ball of yarn. This means that genes can be physically close to the “enhancer” DNA switches that turn ...

After TFs bind to promoter or enhancer regions of the DNA, they interact with other bound TFs and recruit RNA polymerase II. Their influence, however, can be either positive or negative ...