Neuropsychiatric disorders are becoming increasingly prevalent. Given their complex and multifactorial pathogenesis, there is ...

This study identifies 47,350 enhancers active in human neurons during differentiation and links some to genes involved in ...

Understanding enhancer function is very important, since they contain the majority of genetic variants ('mutations') associated with common diseases, such as autoimmune, metabolic and neurological ...

In a 2010 Nature paper, researchers in the lab of neurobiologist Michael Greenberg at Harvard Medical School reported that enhancers can produce RNA. Working with cultured mouse neurons, the ...

“We didn’t think it would work.” The results serve as an extreme example of what scientists are now recognizing as trends among enhancers—that activity can be conserved over long evolutionary ...

Understanding enhancer function is very important, since they contain the majority of genetic variants (‘mutations’) associated with common diseases, such as autoimmune, metabolic and neurological ...

Experiments with shadow enhancers that influence the production of hair-like projections, which are called trichomes, on the bodies of fruit flies showed that, when the researchers deleted these ...

Selective breeding is not considered a form of genetic engineering. Quantifying the function of enhancer sequences is crucial for systems biology. Here, the authors introduce an AI-added strategy ...