The enhancers in this metaphor would be in charge of the amount of ingredients rather than their kind. Using sawdust instead of flour is an example of a genetic mutation, which is similar to ...

Understanding enhancer function is very important, since they contain the majority of genetic variants (‘mutations’) associated with common diseases, such as autoimmune, metabolic and neurological ...

Two other groups had previously used CRISPR to create knockout libraries of protein-coding genes in human cells for functional genetic screens. But the current work is the first genetic screen of ...

A recent study has unveiled the critical roles of two transcription factors, MAFB and CEBPA, in the development of ...

In a study published last month (March 19) in Nature Genetics, scientists found a single genetic enhancer, named ZRS, critical for normal dorsal fin development in Japanese rice fish (Oryzias latipes) ...

More information: Feng Xiao et al, Functional dissection of human cardiac enhancers and noncoding de novo variants in congenital heart disease, Nature Genetics (2024). DOI: 10.1038/s41588-024-01669-y ...

Tissue-specific enhancers can work over long distances. For instance, the enhancer sequences that regulate embryonic expression of Igf-2 in both mice and humans are found more than 100 kilobases ...

When the bat enhancer was knocked into the orthologous ... not to mention the possibility of reverse genetics in the bat, could provide some useful pointers as to the intermediate stages in ...