which allows for greater flexibility in the control of gene expression. As previously mentioned, enhancer sequences are DNA sequences that are bound by an activator protein, and they can be ...

Some of these “enhancers” regulatory sequences function similarly to the dimmer switches that control the lighting in the living room. In fact, when and where a specific gene is needed ...

An international collaboration of researchers led by Masahito Yoshihara at Chiba University (Japan) has identified novel transcriptional enhancers that regulate gene expression in neuronal development ...

In a 2010 Nature paper, researchers in the lab of neurobiologist Michael Greenberg at Harvard Medical School reported that enhancers can produce RNA. Working with cultured mouse neurons, the ...

Researchers used powerful technology to analyse thousands of individual cells at once, considering which genes are active.

Enhancer Biology lab studies gene regulation and genome architecture controlled by transcription factors using genome-wide functional genomics methods. Our aim is to understand enhancer malfunction ...

Two other groups had previously used CRISPR to create knockout libraries of protein-coding genes in human cells for functional genetic screens. But the current work is the first genetic screen of ...

This shows that the region contains several non-modular enhancers (blue = strong gene expression; red = weak gene expression). The image may be used in combination with the press release.

Researchers develop a novel Tle6 gene hetero knockout mice model to understand the role of this gene in male fertility and find that its deficiency results in abnormal sperm structure, reduced ...

Online ahead of print. [PMID: 38775784] (underlined are first author(s) from the Huangfu lab) Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer gene regulatory ...