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Core promoters contain multiple highly conserved cis-motifs interacting with different transcriptional factors like RNA polymerase II, TFIIB, and TFIID.

Core promoters contain multiple highly conserved cis-motifs interacting with different transcriptional factors like RNA polymerase II, TFIIB, and TFIID.

Core promoters contain multiple highly conserved cis-motifs interacting with different transcriptional factors like RNA polymerase II, TFIIB, and TFIID.

Results. Decreased methylation of MIR145 core promoter in pretreatment cfDNA was associated with short-term disease progression (multivariate Cox hazard ratio [HR] 2.027, 95% CI 1.157-3.551, P=0. ...

Instead, these elements predominantly resided within core promoter regions of many more genes (around 8,000), indicating a broader regulatory role beyond typical housekeeping gene functions.

Identifying genes such as ZNF135, ZNF154, ZNF667, and ZNF667-AS1 under the influence of these foundational core promoters, the research suggests their potential as housekeeping tumor suppressor genes.

On average, TFBS tested with JeT and MCK exhibited a lower correlation with other core promoters (R2JeT = 0.14, R2MCK=0.23), suggesting a higher TFBS selectivity of those promoters.

Instead, these elements predominantly resided within core promoter regions of many more genes (around 8,000), indicating a broader regulatory role beyond typical housekeeping gene functions.

Seventeen patients were detected to develop VBTH. In eight of these patients, rtYM204I/VDD resistant mutants were detected during therapy (group Ia YMDD). All eight patients belonging to group Ia ...