ONE of the most frustrating features of primary biliary cirrhosis is pruritus, often so intense and unrelenting that the victim seriously contemplates suicide.1 Such patients suffer from chronic in ...

“Pruritus is commonly associated with primary biliary cholangitis, present in nearly 75% of patients over the disease course,” Cynthia Levy, MD, FAASLD, AGAF, of the University of Miami News News ...

The ongoing, global phase 3 GLISTEN study (ClinicalTrials.gov Identifier: NCT04950127) enrolled 238 adult PBC patients with moderate to severe pruritus who were receiving stable doses of guideline ...

Pruritus, or itching, is a common symptom of Primary Biliary Cholangitis (PBC). Learn more about its impact and the importance of raising awareness about this condition.

Pruritus-related sleep interference was also reduced with linerixibat, with a mean change of -2.77 versus -2.24 (P=0.024), and more patients in the linerixibat group had clinically meaningful itch ...

Reason for decision Anticipate the topic will be of importance to patients, carers, professionals, commissioners and the health of the public to ensure clinical benefit is realised, inequalities in ...

Findings showed treatment with linerixibat led to a statistically significant improvement in pruritus compared with placebo (primary endpoint; least squares [LS] mean difference, -0.72 [95% CI, -1 ...

Tharimmune, Inc. (Nasdaq:THAR) ('Tharimmune' or the 'Company'), a clinical-stage biotechnology company committed to pioneering therapies in immuno ...

Cholestatic pruritus is a common symptom of primary biliary cholangitis (PBC), a rare autoimmune liver disease. Researchers are looking to establish the safety and efficacy of linerixibat – an ...

It is approved for the treatment of cholestatic pruritus in patients with Alagille syndrome in the U.S. (three months and older), in Europe (two months and older), and in other regions globally.

Seladelpar is a drug candidate for the treatment of primary biliary cholangitis that selectively activates PPARδ. 12 PPARδ is unique among PPAR isotypes, with broad expression in cells that play ...

The FDA has accepted for review the NDA for linerixibat for the treatment of cholestatic pruritus in patients with primary biliary cholangitis.