Furthermore, researchers must exercise caution with respect to the specificity of any given mRNA-targeting approach, whether ASO, RNAi, trans-splicing, or ribozyme based, to ensure that only the ...

Many diseases arise through splicing errors, in which mutated genes give rise to primary RNA ... designed ASO can overcome this. “You’re using them to mask critical regions on an mRNA that ...

Then the RNA binding protein communicates to the splicing machinery to include or not include the exon into the mRNA,” Cooper explained. The fit between a splice site and the spliceosome components ...

Alternative RNA splicing is like a movie editor cutting and rearranging scenes from the same footage to create different ...

Natural "off switch" could slow or even reverse the growth of aggressive tumors.

A study reveals how cancer disrupts RNA splicing and presents a potential therapy using antisense oligonucleotides to target ...

Dyne Therapeutics’ DYNE-101 shows positive results in phase 1/2 ACHIEVE study. Read why DYN stock may rise with FDA approval and a $2.78B market opportunity.

RNA splicing, a process discovered in the late 1970s, allows cells to precisely control the content of the mRNA transcripts that carry the instructions for building proteins. Each mRNA transcript ...

Alternative RNA splicing is like a movie editor cutting ... Further studies will refine ASO-based therapies and explore their delivery to tumors. However, preliminary data suggest that ASOs ...