Polyadenylation helps the mRNA cross the nuclear membrane and to link up with ribosomes. Yet, sometimes 3'-end processing factors start polyadenylation earlier in the transcript, shortening the mRNA ...

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Polyadenylation is a critical step in eukaryotic messenger-RNA (mRNA) processing that involves the addition of a long stretch of adenosines (polyadenylated tail) in the 3’ end of mRNA.

Researchers with an interest in unraveling gene regulation in human health and disease are expanding their horizons by closely looking at alternative polyadenylation (APA), an under-charted ...

To understand their regulatory principles, we developed expressRNA, a web platform encompassing computational tools for integration of the QuantSeq 3´ mRNA-Seq, iCLIP and RNA motif analyses. This ...

Meet PolyA-miner, a new computational tool that enables scientists to evaluate the contribution of alternative polyadenylation to gene regulation in health and disease.