Hazmat crews have responded to a chemical spill in Anderson County, South Carolina. Anderson County fire officials said ...

Each week on WYFF News 4, we will introduce you to new businesses, activities, restaurants, events, etc. in the Upstate area ...

South Carolina State Senator Josh Kimbrell, who announced his candidacy for governor in June, will hold a news conference ...

Upstate Pride SC holds an annual LGBTQ+ march and festival each fall in Spartanburg. It might add a film festival and night ...

A heat dome has engulfed the South, Midwest, and East, bringing oppressive temperatures that are forecast to linger in the ...

Authorities arrest Mayo Levord Pickens in Upstate SC, seizing over 165 pounds of cocaine and firearms from his residence ...

There's a reason more than 29 billion tourists visit South Carolina each year — nature's beauty is on display year-round. The state's coastal beaches are wildly popular destinations with ...

According to the Centers for Disease Control and Prevention, 1,267 cases of measles had been confirmed in the U.S. as of July 1, 2025, including cases in Palmetto State neighbors Georgia and North ...

The Greenville News, Spartanburg Herald-Journal and Anderson Independent Mail publish a new live-updates-style story regularly with the latest COVID-19 news relevant to our communities in the Upstate.

According to the state’s Office of Regulatory Staff, as of Friday afternoon, nearly 1.25 million power outages were caused by Hurricane Helene's effects across South Carolina. In the Upstate ...

Desiree Gomez greets friends and family followed by her husband, Mohamad Shokair, at Greenville-Spartanburg International ...

GREENVILLE, S.C. (FOX Carolina) - The South Carolina Education Lottery said a man from North Carolina bought a winning ...